I-13 ARE GWAS STUDIES FOR OSTEOARTHRITISWORTH THE EXPENSE?

I-13: The Domestic Hen as Model to Studies Ovarian Cancer

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Phenotype Information Retrieval for Existing GWAS Studies

The database of Genotypes and Phenotypes (dbGaP) is archiving the results of different Genome Wide Association Studies (GWAS). dbGaP has a multitude of phenotype variables, but they are not harmonized across studies. We proposed a method to standardize phenotype variables by classifying similar variables based on semantic distances. We first extracted variables description, enriched them using ...

Are we living at the expense of the developing countries ?

Heritability and GWAS Studies for Monocyte-Lymphocyte Ratio.

The monocyte-lymphocyte ratio (MLR) is a useful biomarker for disease development, but little is known about the extent to which genetic and environmental factors influence MLR variation. Here, we study the genetic architecture of MLR and determine the influence of demographic and lifestyle factors on MLR in data from a Dutch non-patient twin-family population. Data were obtained in 9,501 indiv...

A Bayesian Graphical Model for Genome-wide Association Studies (GWAS)

The present paradigm to analyze GWAS is to perform an exhausting testing of all single SNP associations with the response variable with the major drawback that the selected subset of SNPs has in general a very low predictive value. As a shift to the usual approach, we propose here a general statistical framework for GWAS based on Bayesian graphical modeling and able to: 1) Assess the joint effe...